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Embry-RiddleBiomechanics and Aerospace Laboratory (ERBaL)

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      • Education Enhancement
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    Embry-RiddleBiomechanics and Aerospace Laboratory (ERBaL)

    • Home
    • Team
    • Aerospace-Biomedical
    • Predictive Modeling
    • Biomechanics & Robotics
    • Education Enhancement
    • …  
      • Home
      • Team
      • Aerospace-Biomedical
      • Predictive Modeling
      • Biomechanics & Robotics
      • Education Enhancement
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      • Predictive Modeling: Advancing Musculoskeletal Research

        At ERBAL, we are committed to breaking new ground in computational modeling for musculoskeletal (MSK) systems. Our research aims to enhance predictive capabilities, laying the foundation for next-generation models that can address critical biomedical challenges.

         

        Vision for MSK Modeling

        Musculoskeletal systems are incredibly dynamic, responding to environmental, mechanical, and pathological factors. However, traditional MSK models often fall short in capturing these adaptive processes. At ERBAL, we are focused on integrating advanced machine learning techniques with biological data to address this gap. Our goal is to evolve static models into predictive tools capable of simulating muscle adaptations, force generation, and structural changes under various conditions.

         

        Driving Innovation with Machine Learning

        Our research leverages cutting-edge neural network architectures and proteomic analyses to predict skeletal muscle responses. By combining deep learning with biological insights, we are developing a framework to simulate muscle atrophy progression and evaluate countermeasures. This approach not only enhances our understanding of muscle adaptation but also sets the stage for impactful advancements in rehabilitation and healthcare.

         

        Applications in Extreme Environments

        Our work is particularly relevant for addressing physiological challenges in extreme environments, such as space exploration. The methodologies we are developing have potential applications in mitigating muscle and bone loss experienced during prolonged spaceflight, as well as in addressing conditions like sarcopenia and immobilization-induced atrophy here on Earth.

         

        Collaborative and Interdisciplinary Efforts

        ERBAL’s research is supported by a robust interdisciplinary approach, bridging engineering mechanics and biological sciences. By fostering collaborations with institutions like the University of Central Florida and leveraging state-of-the-art facilities, we aim to push the boundaries of what is possible in predictive MSK modeling.

         

        Looking Ahead

        Through our work, ERBAL is paving the way for transformative breakthroughs in MSK research. By refining our models and expanding their predictive capabilities, we aim to provide the scientific community with powerful tools for understanding and addressing musculoskeletal disorders.

         

        Stay tuned as we continue to make strides in this exciting area of research. For collaboration opportunities or more information, please contact us here

      • Collaborations

        Melanie Coathup, BSc, PhD

        Professor and Director of the Biionix Cluster 

        University of Central Florida

         

        Cassandra Juran, PhD

        Assistant Professor of Aerospace Physiology

        Embry-Riddle Aeronautical University

         

        Emel Sen Kilic, PhD

        Assistant Professor of Aerospace Physiology

        Embry-Riddle Aeronautical University

         

        Publications

        1. Walck, C., Fleming. B., Taylor A.,Mangada, P. A scoping review of current methods and limitations for modelling
          and evaluating ligamentous structures. World Scientific Annual Review of
          Biomechanical. 2023 https://doi.org/10.1142/S2810958923300056
        2. Walck, C., Rivas, T., Flanagan, R., “Developmentof a Silent Speech Interface for Augmented Reality Applications,” InternationalSymposium on Computer Methods in Biomechanics and Biomedical Engineering, Extended Article 2022 https://www.springerprofessional.de/development-of-a-silent-speech-interface-for-augmented-reality-a/23319352
        3. Walck, C., Flanagan, R., Fornito, M., andRivas, T., “Development of a silent speechinterface for augmented reality applications,” 17th International Symposiumon Computer Methods in Biomechanics and Biomedical Engineering and the 6thConference on Imaging and Visualization, Sept. 2021, ABSTRACT BOOK. pg 240.
        4. Sen-Kilic,E., Huckaby, A. B.,Damron, F. H., Barbier, M. P. aeruginosa Type III and Type VI SecretionSystems Modulate Early Response Gene Expression in Type II Pneumocytes in Vitro. BMC Genomics. 2022 May; 23(1):345. https://doi.org/10.1186/s12864-022-08596-3
        5. Horspool,A. M.*, Sen-Kilic, E.*, Malkowski, A. C., Breslow, S. L., Mateu-Borrás,M., et al. Development of an Anti-Pseudomonas aeruginosa Therapeutic Monoclonal Antibody WVDC-5244. Frontiers in Cellular and Infection Microbiology. 2023; 13:1117844. https://doi.org/10.3389/fcimb.2023.1117844 
        6. Halakou,F., Sen-Kilic, E., Cukuroglu, E., Keskin, O., Gursoy, A. Enriching TraditionalProtein-Protein Interaction Networks with Alternative Conformations of Proteins. Scientific Reports. 2017; 7(1):7180. https://doi.org/10.1038/s41598-017-07523-y

      About Us

      Our Mission

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      Contact Us

      Phone/Zoom ID:

      386-226-7418

      christine.walck@erau.edu

      © 2019

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